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Since 1996 / Before 1996 / Patents


1. "Alstonerine, a New Indole Alkaloid from Alstonia muelleriana," J.M. Cook and P.W. LeQuesne, Chem. Commun., 1306-1307 (1969).

2. "The Structure of Alstonisidine: A Novel Dimeric Indole Alkaloid," J.M. Cook and P.W. LeQuesne, J. Org. Chem., 36, 582-586 (1970).

3. "Some Aspects of Drug Usage, Trade and Plant Domestication Among the Yanomamo Indians of Venezuela and Brazil," N. Chagnon, P.W. LeQuesne, and J.M. Cook, Acta Cient. Venezolana, 21, 186?193 (1970).

4. "Yanomamo Hallucinogens: Anthropological, Botanical and Chemical Findings," N. Chagnon, P.W. LeQuesne, and J.M. Cook, Current Anthropology, 12, 72-74 (1971).

5. "Macralstonine from Alstonia muelleriana," J.M. Cook and P.W. LeQuesne, Phytochem., 10, 737-738 (1971).

6. "A Model Iron-Catalyzed Biomimetic Cyclization of a Cyclic Tryptamine N-Oxide," G. Scherer, C. Dorschel, J.M. Cook, and P.W. LeQuesne, J. Org. Chem., 37, 1083-1085 (1971).

7. "Biomimetic Synthesis and Structure of the Bisindole Alkaloid Alstonisidine," D.E. Burke, J.M.Cook, and P.W. LeQuesne, Chem. Commun., 697 (1972).

8. "Biomimetic Synthesis of the Bisindole Alkaloid Macralstonine," D.E. Burke, J.M. Cook, C. DeMarkey, and P.W. LeQuesne, Chem. Commun., 1346-1347 (1972).

9. "Further Alkaloids of Alstonia muelleriana," D.E. Burke, G.A. Cook, J.M. Cook, H. Lazar, K. Heller, and P.W. LeQuesne, Phytochem., 12, 1467-1474 (1973).

10. "Biomimetic Synthesis of Villalstonine and Alstonisidine," D.E. Burke, J.M. Cook, and P.W. LeQuesne, J. Amer. Chem. Soc., 95, 546-553 (1973).

11. "Studies on Vinca Alkaloids. The Structure of Vincarodine," J.P. Kutney, G. Cook. J. Cook, I. Itoh, J. Clardy, J. Fayos, P. Brown, and G. Svoboda, Heterocycles, 2, 73-78 (1974).

12. "11-Methoxyakuammicine from Alstonia muelleriana," J.M. Cook and P.W. LeQuesne, J. Org. Chem., 1367 (1975).

13. "Studies on the Synthesis of Bisindole Alkaloids. Structure and Absolute Configuration of 18'-Epi-4'-Epi-Vinblastine, 18'-Decarbometh-oxy-18'-Epi-4'-Epi-Vinblastine and 18'-Epi-3',4'-Dehydrovinblastine," J.P. Kutney, J. Cook, K. Fuji, A. Treasurywala, J. Clardy, J. Fayos, and H. Wright, Heterocycles, 3, 205-212 (1975).

14. "Total Synthesis of Indole and Dihydroindole Alkaloids. VIII. Studies on the Synthesis of Bisindole Alkaloids in the Vinblastine-Vincristine Series. The Chloro-indolenine Approach," J.P. Kutney, J. Beck, F. Bylsma, J.M. Cook, W. Cretney, K. Fuji, R. Imhof, and A. Treasurywala, Helv. Chim. Acta, 58, 1690-1719 (1975).

15. "Reaction of 1,2 and 1,3 Dicarbonyl Compounds with Dimethyl β-Ketoglutarate. I. Synthesis of Methyl 5,6,7,8-Tetrahydro-5-oxocoumarin-4β3H-Acetate," D. Yang, J. Oehldrich, D. Foerst, and J.M. Cook, J. Org. Chem., 41(4), 743 (1976).

16. "Reactions of Dicarbonyl Compounds with Dimethyl β-Ketoglutarate. II. Simple Synthesis of Compounds of the [10.3.3] and [6.3.3] Propellane Series," J.M. Cook and D. Yang, J. Org. Chem., 41, 1903-1907 (1976).

17. "Pictet-Spengler Condensations in Refluxing Benzene," J. Sandrin, D. Soerens, L. Hutchins, E. Richfield, F. Ungemach, and J.M. Cook, Heterocycles, 4, 1101-1105 (1976).

18. "13C-NMR of 1,3-Disubstituted 1,2,3,4-Tetrahydro-β-Carbolines," J. Sandrin, D. Soerens, and J.M. Cook, Heterocycles, 4, 1249-1255 (1976).

19. "Reactions of Dicarbonyl Compounds with Dimethyl β-Ketoglutarate. IV. Isolation of 1:1 Adducts," J. Oehldrich, M. Mueller, D. Wichman, D. Yang, J.M. Cook, and U. Weiss, J. Org. Chem., 41, 4053-4058 (1976).

20. "Reactions of Dicarbonyl Compounds with Dimethyl β-?Ketoglutarate. V. Simple Synthesis of Tricyclo[6.3.0.01,5]undecane-3,7,9-Trione: A Novel Cyclopentanoid Compound," J. Oehldrich, J.M. Cook, and U. Weiss, Tetrahedron Letters, 4549-4552 (1976).

21. "Reactions of Dicarbonyl Compounds with β-Ketoglutaric Acid III: Synthesis of 4-Hydroxy-3,4-diphenylcyclopent-2-enone-2-carboxylic Acid," J. Oehldrich and J.M. Cook, Can. J. Chem., 55, 82-84 (1977).

22. "Reactions of Dicarbonyl Compounds with Dimethyl β-Ketoglutarate. VI. Revision of the Structure of the Reaction Product of Cyclohexane-1,3-dione and Dimethyl β-Ketoglutarate and Conversion into 4-Substituted-5,6,7,9-Tetrahydro-5-oxo-2-quinolones," J. Oehldrich and J.M. Cook, J. Org. Chem., 42, 889-894 (1977).

23. "Synthesis of 1,2,3,4-Tetrahydro-β-Carbolines," J. Sandrin, D. Soerens, P. Mokry, and J.M. Cook, Heterocycles, 6, 1133-1139 (1977).

24. "Reaction of Carbonyl Compounds with Dimethyl β-Ketoglutarate. Synthesis of Bicyclic Furan Derivatives," O. Campos and J.M. Cook, J. Hetero. Chem., 14(5), 711-715 (1977).

25. "General Method for the Synthesis of [n.3.3]Propellanes, n.3," R. Weber and J.M. Cook, Can. J. Chem., 56, 198-192 (1978).

26. "Synthesis of the Antibiotic (±)-Pyridindolol," G.S. Wu, E. Yamanaka, and J.M. Cook, Heterocycles, 9, 175-183 (1978).

27. "Synthesis of a Tetraketone of the Tetracyclo[5.5.1.0.4,13O10,13]tridecane ("Staurane") Series," R. Mitschka, U. Weiss, and J.M. Cook, J. Am. Chem. Soc., 100, 2973-2974 (1978).

28. "The Spiroindolenine Intermediate: A Review," F. Ungemach and J.M. Cook, Heterocycles, 9, 1089-1119 (1978).

29. "Simple Entry into the 1,6-Diazaphenalene Ring System," M.I. El-Sheikh, J.-C. Chang, and J.M. Cook, Heterocycles, 9, 1561-1570 (1978).

30. "Study of the Pictet-Spengler Reaction in Aprotic Media: Synthesis of the β-Galactosidase Inhibitor, Pyridindolol," D. Soerens, J. Sandrin, F. Ungemach, P. Mokry, G.S. Wu, E. Yamanaka, L. Hutchins, M. DiPierro, and J.M. Cook, J. Org. Chem., 44, 535-545 (1979).

31. "Selenium Dioxide Entry into 3-Acylindoles," O. Campos and J.M. Cook, Tetrahedron Lett., 1025-1028 (1979).

32. "Synthesis of 1,6-Diazaphenalene, a Vinylogous Imidazole," J.-C. Chang, M.I. El-Sheikh, and J.M. Cook, Heterocycles, 12, 903-907 (1979).

33. "Stereospecific Synthesis of Trans-1,3-Disubstituted-1,2,3,4-Tetrahydro β-Carbo-lines," F. Ungemach, M. DiPierro, R. Weber, and J.M. Cook, Tetrahedron Lett., 3225-3228 (1979).

34. "A Convenient Preparation of Cyclopentane-1,2-dione," J. Wrobel and J.M. Cook, Synthetic Commun., 10, 333-337 (1980).

35. "General Method for the Assignment of Stereochemistry of 1,3-Disubstituted-1,2,3,4- Tetrahydro-β-Carbolines by Carbon-13 Spectroscopy," F. Ungemach, D. Soerens, R. Weber, M. DiPierro, O. Campos, P. Mokry, J.V. Silverton, and J.M. Cook, J. Am. Chem. Soc., 102, 6976-6984 (1980).

36. "Selenium Dioxide Oxidations in the β-Carboline Area," O. Campos, M. DiPierro, M. Cain, R. Mantei, A. Gawish, and J.M. Cook, Heterocycles, 14, 975-984 (1980). 37. "New Perspectives on the Semmler-Wolff Aromatization Reaction," M.I. El-Sheikh and J.M. Cook, J. Org. Chem., 45, 2585-2587 (1980).

38. "Stereospecific Synthesis of 1,3-Disubstituted-1,2,3,4-Tetrahydro β-Carbolines," F. Ungemach, M. DiPierro, R. Weber, and J.M. Cook, J. Org. Chem., 46, 164-168 (1981).

39. "General Approach for the Synthesis of Polyquinanes: Stereospecific, Regiospecific Entry into the Tetracyclo[6.6.0.01,5.O8,12]tetradecane System," A. Gawish and J.M. Cook, Tetrahedron Lett., 22, 211-214 (1981).

40. "3-Hydroxymethyl β-Carboline Antagonizes Some Pharmacologic Actions of Diazepam," P. Skolnick, S.M. Paul, K.C. Rice, S. Barker, J.M. Cook, R. Weber, and M. Cain, Eur. J. Pharmacol., 69, 525-527 (1981).

41. "Reaction of Dicarbonyl Compounds with Dimethyl 3-ketoglutarate. Influence of Steric Effects on Success of the Condensation," K. Avasthi, M.N. Deshpande, W.-C. Han, U. Weiss, and J.M. Cook, Tetrahedron Lett., 22, 3475-3478 (1981).

42. "The Chemistry of 1,6-Diazaphenalene. Electrophilic Substitution and Reaction with Singlet Oxygen," K. Avasthi, S.-J. Lee, J.M. Cook, J.E. Pickett, and H.H. Wasserman, Heterocycles, 16, 1453-1461 (1981).

43. "General Approach for the Synthesis of Polyquinanes, Facile Generation of Molecular Complexity via Reaction of 1,2-Dicarbonyl Compounds with Dimethyl 3-keto-glutarate," R. Mitschka, J. Oehldrich, K. Takahashi, J.M. Cook, U. Weiss, and J.V. Silverton, Tetrahedron (Symposium in Print, ed. by L.A. Paquette), 37, 4521-4542 (1981).

44. "Synthesis of 1,6-Diazaphenalene," M.I. El-Sheikh, J.C. Chang, A. Harmon, K. Avasthi, and J.M. Cook, J. Org. Chem., 46, 4188-4193 (1981).

45. "Chemistry of 1,6-Diazaphenalene, Halogenation," S.-J. Lee and J.M. Cook, Heterocycles, 16, 2125-2131 (1981).

46. "Regiospecific Cleavage of Strained Tri- and Tetraquinane β-Diketones via a Retro- Claisen Reaction," W.C. Han, K. Takahashi, J.M. Cook, U. Weiss, and J.V. Silverton, J. Am. Chem. Soc., 104, 318-321 (1982).

47. "Do Benzodiazepine Receptors Play a Role in Sleep Regulation- Studies with the Benzodiazepine Antagonist, 3-Hydroxymethyl-β-Carboline," W. Mendelson, M. Cain, J.M. Cook, S.M. Paul, and P. Skolnick, in "Beta-Carbolines and Isoquinolines," ed. by Earl Usdin, A.R. Liss, Inc., New York, 233-252 (1982).

48. "β-Carbolines and Benzodiazepine Receptors: Structure-Activity Relationships and Pharmacologic Activity," P. Skolnick, E.F. Williams, J.M. Cook, M. Cain, K.C. Rice, J.M. Crawley, and S.M. Paul, in "Beta-Carbolines and Isoquinolines," ed. by Earl Usdin, A.R. Liss, Inc., New York, 253-262 (1982).

49. "β-Carbolines: Synthesis, Neurochemical and Pharmacological Actions on Brain Benzodiazepine Receptors," M. Cain, R. Weber, F. Guzman, J.M. Cook, S.A. Barker, K.C. Rice, and P. Skolnick, J. Med. Chem., 25, 1081-1091 (1982).

50. "Synthesis of 9-Methoxy-1,6-Diazaphenalene," R.W. Weber and J.M. Cook, Heterocycles, 19, 2089-2095 (1982).

51. "Benzodiazepine Receptor-Mediated Experimental 'Anxiety' in Primates," P.T. Ninan, T.M. Insel, R.M. Cohen, J.M. Cook, P. Skolnick, and S.M. Paul, Science, 218, 1332-1334 (1982).

52. "Chemistry of 1,6-Diazaphenalene. Reaction with Alkylating and Acylating Agents," K. Avasthi and J.M. Cook, J. Heterocyclic Chem., 19, 1415-1419 (1982).

53. "Biomimetic Approach to Potential Benzodiazepine Agonists and Antagonists," M. Cain, F. Guzman, J.M. Cook, K.C. Rice, and P. Skolnick, Heterocycles, 19, 1003- 1007 (1982).

54. "Blockade of 3-Carbomethoxy β-Carboline Induced Seizures by Diazepam and the Benzodiazepine Antagonists, Ro 15-1788 and CGS-8216," M. Schweri, M. Cain, J. Cook, S. Paul, and P. Skolnick, Pharmac. Biochem. Behav., 17, 457-460 (1982).

55. "Halogenation of 1,6-Diazaphenalene. Theoretical and Experimental Results," R.W. Weber, S.J. Lee, S. Milosevich, J.M. Cook, and W.B. England, Can. J. Chem., 60, 3049-3054 (1982).

56. "DDQ Oxidations in the Indole Area: Synthesis of Crenatine," M. Cain, R. Mantei, and J.M. Cook, J. Org. Chem., 47, 4933-4936 (1982).

57. "Selenium Dioxide Oxidations in the Indole Area. Synthesis of β-Carboline Alkaloids," M. Cain, O. Campos, F. Guzman, and J.M. Cook, J. Am. Chem. Soc., 105, 907-913 (1983).

58. "Stereocontrolled Synthesis of (±) Modhephene via the Weiss Reaction," J. Wrobel, K. Takahashi, V. Honkan, S. Bertz, G. Lannoye, and J.M. Cook, J. Org. Chem., 48, 139-141 (1983).

59. "Synthesis of Azaphenalenes," S.J. Lee and J.M. Cook, Heterocycles, 20, 87-111 (1983).

60. "A Benzodiazepine Receptor Antagonist Decreases Sleep and Reverses the Hypnotic Actions of Flurazepam," W.B. Mendelson, M. Cain, J.M. Cook, S.M. Paul, and P. Skolnick, Science, 219, 414-416 (1983).

61. "Increased Wakefulness in Rats is Induced by 3-Hydroxymethyl β-Carboline, a Benzodiazepine Antagonist," W. Mendelson and J.M. Cook, Sleep 1982, 6th Eur. Congr. Sleep Res., Zurich 1982, Karger, Basel, 279-281 (1983).

62. "Pictet-Spengler Reactions in Aprotic Media," M. Jawdosiuk and J.M. Cook, J. Org. Chem., 49, 2699-2701 (1984).

63. "Biomimetic Approach to Potential Benzodiazepine Receptor Agonists and Antagonists," F. Guzman, M. Cain, P. Larscheid, T. Hagen, J. Cook, M. Schweri, P. Skolnick, and S. Paul, J. Med. Chem., 27, 564-570 (1984).

64. "Organocuprate Reactions with Cyclopropanes. Evidence for Three Types of Mechanisms and Against Direct Nucleophilic Displacement of β-Cyclopropyl-",β- Unsaturated Ketones," S.H. Bertz, G. Dabbagh, J.M. Cook, and V. Honkan, J. Org. Chem., 49, 1739-1843 (1984).

65. "Isolation of the Key Intermediate in the Formation of cis-Bicyclo[3.3.0]octane-3,7- diones from Dimethyl 3-ketoglutarate and 1,2-Dicarbonyl Compounds," G. Kubiak, U. Weiss, and J.M. Cook, J. Org. Chem., 49, 561-564 (1984).

66. "Structural Features of the Quinidine and Quinine Molecule Necessary for Binding of Drug-Induced Antibodies to Human Platelets," D.J. Christie, R. Weber, P. Mullen, J.M. Cook, and R. Aster, J. Laboratory and Clinical Medicine, 104, 730-740 (1984).

67. "β-Carboline-3-Carboxylate-t-Butyl Ester: A Selective Bz?1 Receptor Antagonist," H.E. Shannon, N.J. Katzman, F. Guzman, and J.M. Cook, Life Sci., 35, 2227-2236 (1984).

68. "Interactions Between the Benzodiazepine Receptor Antagonist Ro 15-1788 (Flumazenil) and the Inverse Agonist BCCE: Behavioral Studies with Squirrel Monkeys," J.E. Barrett, L.S. Brady, J.M. Witkin, J.M. Cook, and P. Larscheid, Life Sci., 36, 1407-1414 (1985).

69. "Midazolam-Ethanol Interactions and Reversal with a Benzodiazepine Antagonist," P. Van Gorder, W. Hoffman, V. Baughman, R. Albrecht, D. Miletich, F. Guzman, and J.M. Cook, Anesth. Analg., 64, 129?135 (1985).

70. "Cerebrovascular and Cardiovascular Metabolic Effects of Flurazapam and a Benzodiazepine Antagonist 3-Hydroxymethyl β-Carboline," W. Hoffman, J.M. Feld, P. Larscheid, J.M. Cook, R.F. Albrecht, and D.J. Miletich, Eur. J. Pharmacol., 106, 585-591 (1985).

71. "A Benzodiazepine Antagonist Inhibits the Cerebral Metabolic and Respiratory Depressant Effects of Fentanyl," N. Naughton, W.E. Hoffman, P. Larscheid, J.M. Cook, R.F. Albrecht, and D.J. Miletich, Life Sci., 36, (23) 2239-2245 (1985).

72. "Synthetic Studies in the β-Carboline Area. New Entry into 4-Substituted and 3,4- Disubstituted β-Carbolines," N. Fukada, M.L. Trudell, B. Johnson, and J.M. Cook, Tetrahedron Lett., 26, 2139-2142 (1985).

73. "Evidence that a Benzodiazepine Receptor Mechanism Regulates the Secretion of Pituitary β-Endorphin Levels in Rats," S. Maiewski, P. Larscheid, J.M. Cook, and G. Mueller, Endocrinology, 117, 474-480 (1985).

74. "General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. Preparation of the Chiral Tetracyclo[6.6.0.01,5O.8,12]tetradecane-3,6,10,13- tetraene," M. Venkatachalam, M. Jawdosiuk, M. Deshpande, and J.M. Cook, Tetrahedron Lett., 26, 2275-2278 (1985).

75. "Studies on the Reaction of 1,2-Dicarbonyl Compounds with Dimethyl 3-Ketoglu-tarate. Steric and Electronic Effects," G. Kubiak and J.M. Cook, Tetrahedron Lett., 26, 2163-2166 (1985).

76. "The Interaction Between Benzodiazepine Antagonists and Barbiturate-Induced Cerebrovascular and Cerebral Metabolic Depression," R.F. Albrecht, J. Cook, W.E. Hoffman, P. Larscheid, D.J. Miletich, and N. Naughton, Neuropharmacology, 24, 957-963 (1985).

77. "General Approach for the Synthesis of Polyquinenes. II. Synthesis of Tetracyclo-[5.5.1.04,13.O10,13]tridecane-2,5,8,11-tetraene," M.N. Deshpande, M. Jawdosiuk, G. Kubiak, M. Venkatachalam, W. Weiss, and J.M. Cook, J. Am. Chem. Soc., 107, 4786-4788 (1985).

78. "General Approach for the Synthesis of Polyquinenes. III. Synthesis of Triquinacene via the Weiss Reaction," S.H. Bertz, G. Lannoye, and J.M. Cook, Tetrahedron Lett., 26, 4695-4698 (1985).

79. "The Isolation and Characterization of a New Tetrahydroprotoberberine Alkaloid from Cordalis clarkei Prain," M.A. Rothera, S. Wehrli, and J.M. Cook, J. Nat. Products., 48, 802-808 (1985).

80. "General Approach to the Synthesis of Polyquinanes," M. Venkatachalam, G. Kubiak, J.M. Cook, and U. Weiss, Tetrahedron Lett., 26, 4863-4866 (1985).

81. "Condensation of Dimethyl-1,3-Acetone dicarboxylate with 1,2-Dicarbonyl Compounds; cis-Bicyclo[3.3.0]octane-3,7-diones," S. Bertz, J.M. Cook, A. Gawish, and U. Weiss, Org. Syn., 64, 27-38 (1985).

82. "Formation of the Tetracyclo[5.4.2.O2,6.O2,9]tridecane Ring-system by a Novel Transannular Aldolization Reaction," M.N. Deshpande, S. Wehrli, M. Jawdosiuk, J.T. Guy, Jr., D.W. Bennett, J.M. Cook, M.R. Depp, and U. Weiss, J. Org. Chem., 5l, 2436-2444 (l986).

83. "Cerebrovascular and Cerebral Metabolic Effects of Physostigmine, Midazolam and a Benzodiazepine Antagonist," W.E. Hoffman, R.F. Albrecht, D.J. Miletich, T.J. Hagen, and J.M. Cook, Anesth. Analg., 65, 639-644 (1986).

84. "Differential Antagonism of Diazepam-Induced Loss of the Righting Response," J. Witkin, J.E. Barrett, J.M. Cook, and P. Larscheid, Pharm. Biochem. and Behavior, 24, 963-965 (1986).

85. "General Approach to the Synthesis of Polyquinanes. Preparation of Trans-Trans-4,8-Diacetoxy-tetracyclo[9.3.0.01,5.p7,11]tetradeca-6-one via the Aldol Approach," M. Venkatachalam, S. Wehrli, G. Kubiak, U. Weiss, and J.M. Cook, Tetrahedron. Lett., 27, 4111-4114 (1986).

86. "Discriminative and Aversive Stimulus Effects of β-Carboline Ethyl Ester in Rhesus Monkeys," K. Takada, G. Winger, J. Cook, P. Larscheid, and J.H. Woods, NIDA. Res. Mon. Ser., 67, 119-124 (1986).

87. "Discriminative and Aversive Properties of β-Carboline-3-Carboxylic Acid Ethyl Ester, a Benzodiazepine Receptor Inverse Agonist, in Rhesus Monkeys," K. Takada, G. Winger, J. Cook, P. Larscheid, and J.A. Woods, Life Sciences, 38, 1049-1056 (1986).

88. "General Approach for the Synthesis of Polyquinenes," M. Venkatachalam, M.N. Deshpande, M. Jawdosiuk, G. Kubiak, S. Wehrli, U. Weiss, and J.M. Cook, Tetrahedron, "Symposium in Print," 42, 1597-1605 (1986).

89. "Synthesis of 3,6-Disubstituted β-Carbolines Which Possess Either Benzodiazepine Antagonist of Agonist Activity," T.J. Hagen, F. Guzman, C. Schultz, J.M. Cook, P. Skolnick, and H. Shannon, Heterocycles, 24, 2845-2855 (l986).

90. "Synthesis of 7,12-Dihydropyrido[3,4-b:5,4-b']diindoles. A Novel Class of Rigid, Planar Benzodiazepine Receptor Ligands," M.L. Trudell, P. Skolnick, A.S. Basile, H.E. Shannon, and J.M. Cook, J. Med. Chem., 30, 456-458 (l987).

91. "The Synthesis of Novel 6-Substituted β-Carbolines Which Behave as Benzodiazepine Receptor Antagonists or Inverse Agonists," T.J. Hagen, P. Skolnick, and J.M. Cook, J. Med. Chem., 30, 750-753 (l987).

92. "Hydrazine Mediated One-Pot Amination-Oxidation Reaction: Facile Synthesis of 4-Amino β-Carbolines and 4-Aminoisoquinolines," M.L. Trudell, N. Fukada, and J.M. Cook, J. Org. Chem., 52, 4293-4296 (l987).

93. "General Approach to the Synthesis of Polyquinenes. IV. Studies Directed Toward the Preparation of Dicyclopenta[cd,gh]pentalene," G. Lannoye and J.M. Cook, Tetrahedron Lett., 23, 4821-4824 (l987).

94. "General Approach to the Synthesis of Polyquinanes, Preparation of Trans-Trans-4,8-Diacetoxy-tetracyclo[9.3.0.0l,5.07,11]tetradeca-6-one," M. Venkatachalam, S. Wehrli, G. Kubiak, U. Weiss, and J.M. Cook, J. Org. Chem., 52, 4110-4115 (l987).

95. "Discriminative Stimulus Effects of Intraveous Nicotine in Squirrel Monkeys," K. Takada, T.J. Hagen, J.M. Cook, S.A. Goldberg, and J.L. Katz, Pharmacol. Biochem. Behav., 30, 243-247 (1988).

96. "General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. V. Progress Toward the Synthesis of Dicyclopentapentalenes," G. Lannoye and J.M. Cook, Tetrahedron Lett., 29, 171-174 (1988).

97. "Synthesis of 1-Methoxycanthine-6-one," T.J. Hagen and J.M. Cook, Tetrahedron Lett., 24, 2421-2424 (1988).

98. "General Approach To The Synthesis of Polyquinenes via the Weiss Reaction. VI. Progress Toward the Synthesis of Dicyclopentapentalenes," G. Lannoye, K. Sambasivarao, S. Wehrli, U. Weiss, and J.M. Cook, J. Org. Chem., 53, 2327-2340 (1988).

99. "β-Carbolines as Antagonists of the Discriminative Stimulus Effects of Diazepam in Rats," H.E. Shannon, T.J. Hagen, F. Guzman, and J.M. Cook, J. Pharm. Exp. Ther., 246, 275-281 (1988).

100. "General Approach to the Synthesis of Polyquinenes. VII. Synthesis of a Centro- substituted Triquinacene," A.K. Gupta and J.M. Cook, Tetrahedron Lett., 24, 2535-2538 (1988).

101. "Regioselective Methylation of 7,12-Dihydropyrido[3,2-b':5,4-b']diindole. Experi-mental and Computational Results," M.L. Trudell, Y.-C. Tan, and J.M. Cook, J. Org. Chem., 53, 4873-4875 (1988).

102. "Antibody-Mediated Platelet Destruction by Quinine, Quinidine and Their Metabolites," D.J. Christie, H. Diaz-Arauzo, and J.M. Cook, J. Laboratory and Clinical Medicine, 112, 92-98 (1988).

103. "Synthesis of Novel 3-Substituted β-Carbolines as Benzodiazepine Receptor Ligands: Probing the Benzodiazepine Receptor Inverse Agonist Site," M.S. Allen, T.J. Hagen, M.L. Trudell, P. Skolnick, and J.M. Cook, J. Med. Chem., 31, 1854-1861 (1988).

104. "General Approach to the Synthesis of Polyquinenes. IX. The Monofunctional-ization and Alteration of the Symmetry of the cis-Bicyclo[3.3.0]octane-3,7-dione Unit," G. Lannoye, G. Kubiak, K. Sambasivarao, and J.M. Cook, J. Org. Chem., 53, 5173-5175 (1988).

105. "Pictet-Spengler Reactions in Aprotic Media. Nb-Benzyl Promoted Retention of Optical Activity in the Synthesis of an Indolo-substituted Aza-bicyclo[3.3.1]nonane. A Key Template for the Synthesis of Macroline Alkaloids," L.H. Zhang and J.M. Cook, Heterocycles, 27, 2795-2803 (1988).

106. "Reactivity of 7,12-Dihyropyrido[3,2?b:5,4?6]diindoles with Electrophilic Reagents. Experimental and Computational Results," M.L. Trudell, S.L. Lifer, Y.-C. Tan, W.B. England, and J.M. Cook, J. Org. Chem., 53, 4185-4190 (1988).

107. "Structure-activity Studies of β-Carbolines, Crystal and Molecular Structures of t-Butyl-β-Carboline-3-Carboxylate and 2-(Methoxycarbonyl) Canthine-6-one," P.W. Codding, M.B. Szkaradzinska, A. Roszak, L.J. Aha, T.J. Hagen, and J.M. Cook, Can. J. Chem., 66, 2981-2986 (1988).

108. "Similarity of the Discriminative Stimulus Effects of N-Methyl-D-Aspartate and β-Carboline Ethyl Ester in Pigeons," J.H. Woods, C.P. France, J. Hartman, S. Baron, and J.M. Cook in "Frontiers in Excitatory Amino Acid Research," E.A. Cavalheiro, J. Lehmann, and L. Turski (Ed.), A.R. Liss, New York, N.Y., 317-324 (1988).

109. "3-Ethoxy β-Carboline: A High Affinity Benzodiazepine Receptor Ligand with Partial Inverse Agonist Properties," R. Trullas, H. Ginter, B. Jackson, P. Skolnick, M. Allen, T. Hagen and J.M. Cook, Life Sci., 43, 1189-1197 (1988).

110. "Pictet-Spengler Reactions in Aprotic Media. Stereospecific Conversion of Optically Active cis-1,3-Disubstituted β-Carbolines into Their Corresponding Trans Diastere-omers," L.H. Zhang and J.M. Cook, Heterocycles, 27(6), 1357-1363 (1988).

111. "Synthesis of 7,12-Dihydropyridopyrroloindoles(Azapyridodiindoles) via the Fischer Indole Cyclization. A Search for Water Soluble Benzodiazepine Receptor Ligands," Y.-C. Tan, M.L. Trudell and J.M. Cook, Heterocycles, 27(7), 1607-1614 (1988).

112. "Punishment of Behavior with Response-produced Injections of Drugs in Squirrel Monkeys," J.L. Katz, K. Takada, J.E. Barrett and J.M. Cook, Psychopharmacol., 96, S30 (1988).

113. "General Approach to the Synthesis of Polyquinenes. VIII. Synthesis of Triquinacene, 1,10-Dimethyltriquinacene and 1,10-Cyclohexanotriquinacene," A.K. Gupta, G. Lannoye, G. Kubiak, J. Schkeryantz, S. Wehrli and J.M. Cook, J. Am. Chem. Soc., 11, 2169-2179 (1989).

114. "Modeling the Benzodiazepine Receptor Using Structural and Theoretical Characterization of Novel β-Carbolines," P.W. Codding, A.W. Roszak, M.B. Szkaradzinska, J.M. Cook, and L.J. Aha, Trends in Medicinal Chemistry "88, H. Van der Goot, G. Domany, L. Pallos, and H. Timmerman (eds.), Budapest Hungary, August 1988, Pharmochemistry Library, Elsevier Science Publishers, Amsterdam, The Netherlands, 109-120 (1989).

115. "Drug Discrimination in Pentylenetetrazol-Trained Baboons: Generalization to Buspirone and β-CCE But Not Lorazepam or Pentobarbital," N.A. Ator, J.M. Cook, and R.R. Griffiths, Drug Dev. Res., 16, 257-267 (1989).

116. "Behavioral Effects of Benzodiazepine Antagonists in Chlordiazepoxide Tolerant and Non-Tolerant Rats," K. Takada, T. Suzuki, T.J. Hagen, J.M. Cook, and J.L. Katz, Life Sci., 44, 289-299 (1989).

117. "DDQ Oxidations in the Indole Area. Synthesis of 4-Alkoxy β-Carbolines Including the Natural Products Crenatine and 1-Methoxy Canthine-6-one," T.J. Hagen, K. Narayanan, J. Names and J.M. Cook, J. Org. Chem., 54, 2170-2178 (1989).

118. "Studies on the Formation of Oxindoles From Their Azabicyclo[3.3.1]nonane Counterparts and the Implications for the Biogenesis of Alstonisine," S.P. Hollinshead, D.S. Grubisha, D.W. Bennett and J.M. Cook, Heterocycles, 29, 529-537 (1989).

119. "Reinvestigation of the Mechanism of the Acid Catalyzed Epimerization of Reserpine to Isoreserpine," L.-H. Zhang, A.K. Gupta and J.M. Cook, J. Org. Chem., 54, 4708-4712 (1989).

120. "Inhibition of Sleep and Benzodiazepine Receptor Binding by a β-Carboline Derivative," Joseph V. Martin, P. Skolnick, J.M. Cook and T.J. Hagen, and W.B. Mendelson, Pharm. Biochem. Behav., 34, 37-42 (1989).

121. "Behavioral Differentiation of Benzodiazepine Ligands After Repeated Administration in Baboons," C.A. Sannerud, J.M. Cook and R.R. Griffiths, Eur. J. Pharmacol., 167, 333-343 (1989).

122. "Total Synthesis of (±) Suaveoline," M.L. Trudell and J.M. Cook, J. Am. Chem. Soc., 111, 7504-7507 (1989).

123. "Pictet-Spengler Reactions in Aprotic Media. Stereospecificity in the Pictet-Spengler Reaction," J. Sandrin, S.P. Hollinshead and J.M. Cook, J. Org. Chem., 54, 5636-5640 (1989).

124. "[3,3,]Sigmatropic Rearrangements in Indoloazabicyclo[3,3,1]nonene Systems, Reversal of the Stereofacial Selectivity in the Claisen vs. Orthoester Claisen Rearrangement," S.P. Hollinshead, L.-H. Zhang, M. Trudell and J.M. Cook, J. Am. Chem. Soc., 111, 8263-8265 (1989).

125. "Structural Requirements for Agonist Actions at the BzR: Studies with Analogs of ZK-93423," S.P. Hollinshead, M.L. Trudell, P. Skolnick and J.M. Cook, J. Med. Chem., 33, 1062-1069 (1990).

126. "Synthesis of 10,11-Dihydroxydihydroquinidine N-oxide, A New Metabolite of Quinidine. Preparation and Proton NMR Spectroscopy of the Metabolites of Quinine and Quinidine and Conformational Analysis via 2-D COSY NMR Spectroscopy," H. Diaz-Arauzo, D.J. Christie and J.M. Cook, J. Nat. Prod., 53, 112-124, (1990).

127. "Synthetic and Computer-Assisted Analyses of the Pharmacophore of the Benzodiazepine Receptor Inverse Agonist Site," M.S. Allen, Y.-C. Tan, M.L. Trudell, K. Narayanan, L.R. Schindler, M. Martin, C. Schultz, T.J. Hagen, K.F. Koehler, P.W. Codding, P. Skolnick and J.M. Cook, J. Med. Chem., 33, 2343-2357 (1990).

128. "Synthesis of 7,12-Dihydropyrido[3,2-b:5,4b']diindoles: Rigid Planar Templates of the Inverse Agonist/Antagonist Benzodiazepine Receptor Binding Site," M.L. Trudell, Sherry Lifer, Y.-C. Tan, M.J. Martin, Li Deng, P. Skolnick and J.M. Cook, J. Med. Chem., 33, 2412-2420 (1990).

129. "Molecular Yardsticks: Synthesis of Higher Homologs of 7,12-Dihydropyrido-[3,4-b:5,4-b']diindole. Probing the Dimensions of the Benzodiazepine Receptor Inverse Agonist Site," K. Narayanan and J.M. Cook, Heterocycles, 31, (2), 203-209 (1990).

130. "General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. XI. Transient Formation of cis-Tetracyclo[7.2.1.04,11.06,10]dodeca-3,5,7,9-tetraene and Approach Toward 10,11-Dimethyl-cis-Tetracyclo[7.2.1.04,11.06,10]dodeca-3,5,7,9-tetraene," A.K. Gupta, K. Sambasivarao, B. Opansky and J.M. Cook, J. Org. Chem.,, 55, 4480-4483 (1990).

131. "General Approach to the Synthesis of Polyquinenes via the Weiss Reaction. II. Synthetic Approach to Pentaleno[2,1-b:5,4-b']diindoles," K. Sambasivarao, S.P. Hollinshead, D. Grubisha, F. Laib, D.W. Bennett, and J.M. Cook, J. Org. Chem., 55, 3858-3866 (1990).

132. "Carboxyl-Mediated Pictet-Spengler Reaction. Direct Synthesis of 1,2,3,4-Tetrahydro β-Carbolines from Tryptamine 2-Carboxylic Acids," K. Narayanan and J.M. Cook, Tetrahedron Lett., 31, 3397-3400 (1990).

133. "General Approach to the Synthesis of Macroline-Related Alkaloids. Stereospecific Total Synthesis of (!)!Alstonerine," L.-H. Zhang and J.M. Cook, J. Am. Chem. Soc., 112, 4088-4090 (1990).

134. "Improved Method for Bisallylation of cis-Bicyclo[3.3.0]octane-3,7-dione via the Claisen Rearrangement," K. Sambasivarao and J.M. Cook, Org. Prep. and Procedures. International, 22(5), 630-632 (1990).

135. "General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. XII. The Chugaev Approach to Ellacene (1,10-Cyclododecanotriquinacene). X. Fu and J.M. Cook, Tetrahedron Lett., 31, 3409-3412 (1990).

136. "General Approach for the Synthesis of Polyquinenes via the Weiss Reaction XIII. Aldol Approach to Fenestranes," G. Kubiak, X. Fu, A. Gupta and J.M. Cook,Tetrahedron Lett., 31, 4285-4288 (1990).

137. "Stereospecificity in the Pictet?Spengler Reaction. Kinetic vs. Thermodynamic Control," L. Deng, K. Czerwinski and J.M. Cook, Tetrahedron Lett., 32, 175?178 (1991).

138. "Carboxyl-Mediated Pictet-Spengler Reaction. Direct Synthesis of 1,2,3,4- Tetrahydro β-carbolines From Tryptamine-2-carboxylic Acids," K. Narayanan, L. Schindler and J.M. Cook, J. Org. Chem., 56, 359-365 (1991).

139. "Inverse Agonists. Probes to Study the Structure, Topology and Function of the Benzodiazepine Receptor," J.M. Cook, H. Diaz-Arauzo, and M.S. Allen, presented at the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence, Inc., June 10-14, 1990, Richmond, Virginia. NIDA Research Monograph Series, 133-139 (1991).

140. "General Approach for the Synthesis of Polyquinenes via the Weiss Reaction," A.K. Gupta, X. Fu, J.P. Snyder and J.M. Cook, Tetrahedron Report Number 291, Tetrahedron, 47, 3665-3720 (1991).

141. "Synthetic and Computer Assisted Analysis of the Pharmacophore for Agonists at Benzodiazepine Receptors," H. Diaz-Arauzo, K. Koehler, T. Hagen and J.M. Cook, Life Sci., 49, 207-216 (1991).

142. "The Agonist Pharmacophore of the Benzodiazepine Receptor. Synthesis of a Selective Anticonvulsant/Anxiolytic," H. Diaz-Arauzo, G. Evoniuk, P. Skolnick and J.M. Cook, J. Med. Chem., 34, 1754-1756 (1991).

143. "Structure of 2-Chloro-7,12-dihydropyrido[3,2-b:5,4-b']diindole," M.B. Szkaradzinska, A. Roszak, M.L. Trudell, J.M. Cook and P.W. Codding, Acta Crystallographica, C48, 382-384 (1991).

144. "Carboxy?Mediated Pictet-Spengler Reaction. Improved Synthesis of 2,3,5,6,11,11b-Hexahydro-3-OXO-1H-indolizino[8,7-b]indoles from Tryptamine-2-Carboxylic Acids," K. Narayanan and J.M. Cook, J. Org. Chem., 56, 5733-5736 (1991).

145. "DDQ Oxidation of Ring-A Methoxylated 11b-Methoxycarbonyl- 2,3,5,6,11,11b- Hexahydro-3-OXO-1H-indolizino[8,7-b]indoles," K. Narayanan and J.M. Cook, Heterocycles, 32, 2005-2015 (1991).

146. "Behavioral Effects of Benzodiazepine Ligands in Non-Dependent, Diazepam Dependent and Diazepam Withdrawn Baboons," C.A. Sannerud, M. Allen, J. M. Cook and R.R. Griffiths, Eur. J. Pharmacol., 202, 159-169 (1991).

147. "Pictet-Spengler Reactions in Aprotic Media. The Total Synthesis of (±) Suaveoline," M.L. Trudell, D. Soerens, R. Weber, L. Hutchins, D. Grubisha, D. Bennett and J.M. Cook, Tetrahedron, 48, 1805-1822 (1992).

148. "Synthesis of Novel 2-Phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: Topological Comparisons with Analogues of 2-Phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)- ones at Benzodiazepine Receptors," M.S. Allen, P. Skolnick and J.M. Cook, J. Med. Chem., 35, 368-374 (1992).

149. "Stereospecificity in the Pictet-Spengler Reaction. Enantiospecific Synthesis of (6S,10S) (-)-5-Methyl-9-oxo-12-Benzyl-6,7,8,9,10,11-Hexahydro-6,10-Imino-5H-cyclooct[b]indole, A Template for the Preparation of Macroline/Sarpagine Alkaloids," L.-H. Zhang, Y. Bi, F. Yu, G. Menzia and J.M. Cook, Heterocycles, 34 (3), 517-547 (1992).

150. "Punishment of Schedule-Controlled Behavior with β-Carboline Injections: Anta-gonism and Comparisons with Other Compounds," K. Takada, J. Barrett, M.S. Allen, J.M. Cook and J.L. Katz, J. Pharmacol. and Exp. Thera., 261, 138-145 (1992).

151. "The Synthesis of Polyquinanes and Polyquinenes via the Weiss Reaction," X. Fu and J.M. Cook, Aldrich Chimica Acta, 25, 43-54 (1992).

152. "Enantiospecific Total Synthesis of the Ajmaline Related Alkaloids (!)?Suaveoline, (-)Raumacline and (-)NbMethylraumacline," X. Fu and J.M. Cook, J. Am. Chem. Soc., 114, 6910-6912 (1992).

153. "Mechanism Driven Trans Stereospecificity in the Pictet-Spengler Reaction. Stereospecific Formation of Trans-1,2,3-Trisubstituted-tetrahydro β-Carbolines by Condensation of Nb-Diphenylmethyl-tryptophan Isopropyl Esters with Aldehydes," K. Czerwinski, L. Deng and J.M. Cook, Tetrahedron Lett., 33, 4721-4724 (1992).

154. "Predictive Binding of β-Carboline Inverse Agonists and Antagonists via the CoMFA/ GLOPE Approach," M.S. Allen, A. LaLoggia, L. Dorn, M.J. Martin, G. Costantino, T.J. Hagen, K. Koehler, P. Skolnick and J.M. Cook, J. Med. Chem., 35, 4001-4010 (1992).

155. "Entry into 6-Methoxy-D(+)-Tryptophans. Stereospecific Synthesis of 1-Benzene-sulfonyl-6-methoxy-D(+)-tryptophan Ethyl Ester," M. Allen, L. Hamaker, A. LaLoggia and J.M. Cook, Synthetic Comm., 22, (14) 2077-2102 (1992).

156. "The Agonist Pharmacophore of the Benzodiazepine Receptor. Synthesis of a Selective Anticonvulsant/Anxiolytic," H. Diaz-Arauzo, P. Skolnick and J.M. Cook, National Institute on Drug Abuse Research Monograph Series 119, Problems of Drug Dependence 1991: Proceedings of the 53rd Annual Scientific Meeting, p. 354 (1992).

157. "General Approach for the Synthesis of Polyquinenes via the Weiss Reaction. XIV. Synthesis of Ellacene (1,10-Decanotriquinacene) and Studies of the Proposed Dimerization to a Substituted Dodecahedrane," X. Fu and J.M. Cook, J. Org. Chem., 57, 5121-5128 (1992).

158. "Molecular Yardsticks. Rigid Planar Ligands to Define the Spatial Dimensions of the Benzodiazepine Receptor Binding Site," M. Martin, M.L. Trudell, H. Diaz-Arauzo, M.S. Allen, A. LaLoggia, Li Deng, C.A. Schultz, Y.-C. Tan, Y. Bi, K. Narayanan, L. Dorn, K. Koehler, P. Skolnick and J.M. Cook, J. Med. Chem., 35, 4105-4117 (1992).

159. "High Pressure Raman Studies of Triquinacene and Dodecahedrane," S.H. Bertz, G.A. Kourouklis, A. Jayaraman, G. Lannoye and J.M. Cook, Can. J. Chem., 71, 352-357 (1993).

160. "The Synthesis of Macroline Related Alkaloids," Y. Bi, L. Hamaker and J.M. Cook, chapter of a book titled Studies in Natural Products Chemistry, Bioactive Natural Products, Part A, A.T. Rahman and F. Basha, eds., Elsevier, Amsterdam, Volume 13, pp. 383-432 (1993).

161. "General Approach for the Synthesis of Polyquinenes via the Weiss Reaction XV. Synthesis of the [5.5.5.5]Fenestrane System via the Aldol Approach and Studies Directed Toward the [5.5.6.6]Fenestranes," X. Fu, G. Kubiak, W. Zhang, W. Han, A.K. Gupta and J.M. Cook, Tetrahedron, 49, 1511-1524 (1993).

162. "Novel Pyridodiindoles, Azadiindoles and Indolopyridoimidazoles via the Fischer- Indole Cyclization," M. Martin, L.J. Dorn and J.M. Cook, Heterocycles, 36, 157-189 (1993).

163. "Synthetic and Computer-Assisted Analysis of the Structural Requirements for Selective, High-Affinity Ligand Binding to Diazepam-Insensitive Benzodiazepine Receptors," G. Wong, K.F. Koehler, P. Skolnick, Z-Q. Gu, S. Ananthan, P. Schönholzer, W. Hunkeler, W. Zhang and J.M. Cook, J. Med. Chem., 36, 1820-1830 (1993).

164. "General Approach to the Synthesis of the Ajmaline-Related Alkaloids. Enantio-specific Total Synthesis of (-)Suaveoline, (-)Raumacline and (-)Nb Raumacline," X. Fu and J.M. Cook, J. Org. Chem., 58, 661-672 (1993).

165. "Novel Organic Reactions in the Search for Anxioselective Anxiolytics at the Benzodiazepine Receptor," W. Zhang and J.M. Cook, in Drug Design for Neuroscience, Ed. by A. Kozikowski, Raven Press, New York, 87-117 (1993).

166. "Evaluation of Substituted β-Carbolines as Noncompetitive Indoleamine 2,3-Dioxy-genase Inhibitors," A.C. Peterson, A.J. La Loggia, L.K. Hamaker, R.A. Arend, P.L. Fisette, Y. Ozaki, J.A. Will, R.A. Brown and J.M. Cook, Med. Chem. Res, 3, 473-482, (1993).

167. "The Regiospecific Synthesis of Ortho Aminonaphthophenones via the Addition of Carbanions to Naphthoxazine-4-ones," W. Zhang, R.Y. Liu and J.M. Cook, Heterocycles, 36, 2229-2236 (1993).

168. "General Approach for the Synthesis of Macroline/Sarpagine Alkaloids. The Total Synthesis of (+)-Macroline," Y. Bi and J.M. Cook, Tetrahedron Lett., 34, 4501-4504 (1993).

169. "Discriminative-stimulus Effects of Azaspirodecanedione Anxiolytics in Baboons Trained to Discriminate β-Carboline-3-carboxylic Acid Ethyl Ester or Pentylene-tetrazole," N.A. Ator, J.M. Cook, M.S. Allen and R.R. Griffiths, Behav. Pharmacol., 5, 176-188 (1994).

170. "Epoxide Metabolite of Quinine and Inhibition of the Multidrug Resistance Pump in Human Leukemic Lymphoblasts," P. Wigler, K.Lyon, F. Patterson, A. LaLoggia, H. Diaz-Arauzo, M. Sreenivasa Reddy and J.M. Cook, Mol. Pharmacol., 46, 563-567 (1994).

171. "Synthesis of Benzo-Fused Benzodiazepines Employed as Probes to Study the Agonist Pharmacophore of the Benzodiazepine Receptor," W. Zhang, P. Skolnick, K. Koehler, B. Harris and J.M. Cook, J. Med. Chem., 37, 745-757 (1994).

172. "Evaluation of Functionalized Tryptophan Derivatives and Related Compounds as Competitive Inhibitors of Indoleamine 2,3-Dioxygenase," A.C. Peterson, M.T. Migawa, M.M. Martin, L.K. Hamaker, K.C. Czerwinski, Wei Zhang, R.A. Arend, P.L. Fisette, Y. Ozaki, J.A. Will, R.R. Brown and J.M. Cook, Med. Chem. Res., 4, 531-544 (1994).

173. "Studies on the Enantiospecific Synthesis of Oxindole Alkaloids," A. Peterson and J.M. Cook, Tetrahedron Lett., 35, 2651-2654 (1994).

174. "The Enantiospecific Synthesis of (-)Alstonerine, and (+)Macroline, as Well as a Partial Synthesis of (+)Villastonine," Y. Bi, L.-H. Zhang, L. Hamaker and J.M. Cook, J. Am. Chem. Soc.,116, 9027-9041 (1994).

175. "Facile Formation of Dihydroacepentalene Dianions from Centro-Substituted Tribenzotriquinacenes with C-C Bond Cleavage," R. Haag, D. Kuck, X. Fu, J.M. Cook and A. de Meijere, Synlett., 340-342 (1994).

176. "A Partial Synthesis of the Alstonia Bisindole Alkaloid Villalstonine," Y. Bi, P. LeQuesne and J.M. Cook, Tetrahedron Lett., 35, 3877-3878 (1994).

177. "The Synthesis of Roeharmine and (-)1,2,3,4-Tetrahydroroeharmine", M.S. Reddy and J.M. Cook, Tetrahedron Lett., 35, 5413-5416 (1994).

178. "Weiss's Endo- and Exo-Tetracyclo[5.5.1.02,6.010,13]tridecane-4,8,12-trione: Analysis of 1H-NMR Couplings in a System of Fused 5-Membered Rings," S.H. Bertz, W. Zhang, J.M Cook, M.D. Bruch and L. Jelinski, Can. J. Chem., 72, 1926-1932 (1994).

179. "Development of a Comprehensive Pharmacophore Model for the Benzodiazepine Receptor," W. Zhang, K. Koehler, P. Zhang and J.M. Cook, Drug Design and Discovery., 12, 193-248 (1995).

180. "The Synthesis of Macroline Related Sarpagine Alkaloids," L.K. Hamaker and J.M. Cook, "Alkaloids: Chemical and Biological Perspectives," Ed. by W. Pelletier, Elsevier Science, Oxford, Vol. 9, 23-84 (1995).

181. "Structure-Activity Relationships in Antagonist and Inverse Agonist Ligands for the Benzodiazepine Receptor," P.W. Codding, A.W. Roszak, M.B. Szaradzinska, J.M. Cook, T.J. Hagen and M.S. Allen, Can. J. Chem., 73, 449-512 (1995).

182. "Dimethyl 1,3-acetonedicarboxylate," M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 3, 1989-1992 (1995).

183. "Butane-2,3-dione," M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 2, 817-819 (1995).

184. "Glyoxylic acid," M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 4, 2620-2622 (1995).

185. "Glyoxal," M.R. Reddy and J.M. Cook, Encyclopedia of Reagents for Organic Synthesis, Ed. by L.A. Paquette, John Wiley & Sons, New York, 4, 2616-2618 (1995).

186. "The Synthesis of 5-Thienyl and -Furyl Substituted Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors," W. Zhang, R. Liu, Qi Huang, B. Harris, P. Skolnick and J.M. Cook, Eur. J. Med Chem., 30, 483-496 (1995).

187. "Synthesis and SAR Study of Novel Imidazobenzodiazepines at 'Diazepam-insensitive' Benzodiazepine Receptors," P. Zhang, W. Zhang, R. Liu, B. Harris, P. Skolnick and J.M. Cook, J. Med. Chem., 38, 1679-1688 (1995).

188. "Studies Directed Toward the Enantiospecific Synthesis of Gardeneria, Voacanga, and Alstonia Oxindole Alkaloids," A.C. Peterson and J.M. Cook, J. Org. Chem., 60, 191-193 (1995).

189. "Regiospecific Bromination of 3-Methylindoles with N-Bromosuccinimide," P. Zhang, R. Liu and J.M. Cook, Tetrahedron Lett., 36, 3103-3106 (1995).

190. "Enantiospecific Synthesis of 5-Methoxy-D(+)- or L(-) Tryptophan," P. Zhang and J.M. Cook, Syn. Commun., 25, 3883-3900 (1995).

191. "The Pictet-Spengler Condensation: New Directions for an Old Reaction," E. Cox and J.M. Cook, Chem. Rev., 95, 1797-1842 (1995).

192. "Synthesis of Novel Imidazobenzodiazepines Selective for the "α5β2γ2 (Bz5) GABAA/ Benzodiazepine Receptor Subtype," R. Liu, P. Zhang, R. McKernan, K. Wafford, and J.M. Cook, Med. Chem. Res., 5, 700-709 (1995).

193. "Studies of Novel Imidazobenzodiazepine Ligands at GABAA/BzR Subtypes: Effect of C(3) Substituents on Receptor Site Selectivity," P.W. Zhang, R. Liu, R. McKernan, K. Wafford and J.M. Cook, Med. Chem. Res., 5, 487-495 (1995).

194. "A Successful Acid Promoted Asymmetric Pictet-Spengler Reaction of Na-BOC Protected Tryptophans. Effect of the BOC Group on Reactivity and Stereoselectivity," P.W. Zhang and J.M. Cook, Tetrahedron Lett., 36, 6999-7002 (1995).

195. "Bz1 Receptor Subtype Specific Ligands. Synthesis and Biological Properties of βCCt, A Bz1 Receptor Subtype Specific Antagonist," E. Cox, T. Hagen, R. McKernan and J.M. Cook, Med. Chem. Res., 5, 710-718 (1995).

196. "An Enantiospecific Synthesis of L(-) and D(+)-6-Chloro-5-hydroxytryptophan: An Unusual Amino Acid Residue from the Cyclic Hexapeptide Keramamide A," P. Zhang, R. Liu and J.M. Cook, Tetrahedron Lett., 36, 7411-7414 (1995).

197. "A Concise Synthesis of Optically Active 2-Bromotryptophan Amino Acids Present in Konbamide and Jaspamide via a Regiospecific Bromination Procedure," P. Zhang, R. Liu and J.M. Cook, Tetrahedron Lett., 36, 9133-9136 (1995).

Since 1996 / Before 1996 / Patents