Publications

2014

Balderston, N. L., Schultz, D. H., Baillet, S., Helmstetter, F.J.
Rapid amygdala responses during trace fear conditioning without awareness
PLOS ONE, 9(5). e96803

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Gilmartin, M.R., Balderston, N.L., Helmstetter, F.J.
Prefrontal cortical regulation of fear learning
Trends in Neuroscience, 37(8), 455-464

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Jarome, T.J., Kwapis, J.L., Hallengren, J.J., Wilson, S.M., Helmstetter, F.J.
The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation
Learning and Memory, 21, 748-751

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Jarome, T.J., Helmstetter, F.J.
Protein degradation and protein synthesis in long-term memory formation
Frontiers in Molecular Neuroscience, 7:61

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Kwapis, J.L., Helmstetter, F.J.
Does PKM(zeta) maintain memory?
Brain Research Bulletin, 105, 36-45

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Kwapis, J.L., Jarome, T.J., Lee, J.L., Gilmartin, M.G., Helmstetter, F.J.
Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala
Neurobiology of Learning and Memory, 113, 41-54

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2013

Reis, D.S., Jarome, T.J., Helmstetter, F.J.
Memory formation for trace fear conditioning requires ubiquitin-proteasome mediated protein degradation in the prefrontal cortex
Frontiers in Behavioral Neuroscience 7:150, 107-116

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Jarome, T.J., Helmstetter, F.J.
The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation
Neurobiology of Learning and Memory 105, 107-116

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Jarome, T.J., Kwapis, J.L., Ruenzel, W.L., Helmstetter, F.J.
CamKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories
Frontiers in Behavioral Neuroscience 7:115

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Gilmartin, M.R., Miyawaki, H., Helmstetter, F.J., Diba, K.
Prefrontal activity links nonoverlapping events in memory
Journal of Neuroscience 33(26), 10910-10914

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Balderston, N.L., Schultz, D.H., Baillet, S., Helmstetter, F.J.
How to detect amygdala activity with magnetoencephalography using source imaging
Journal of Visulaized Experiments 3(76)

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Schultz, D.H., Balderston, N.L., Geiger, J.A., Helmstetter, F.J.
Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans
Behavioral Neuroscience 127(3), 357-368

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Gilmartin, M.R., Kwapis, J.L., Helmstetter, F.J.
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Learning and Memory 20(6), 290-294

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Balderston, N.L., Schultz, D.H., Helmstetter, F.J.
The effect of threat on novelty evoked amygdala responses
PLoS One 8(5)

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Gafford, G.M., Parsons, R.G., Helmstetter, F.J.
Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory
Hippocampus 23(9), 842-847

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2012

Schultz, D.H., Balderston, N.L., Helmstetter, F.J.
Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning
Frontiers in Human Neuroscience

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Gilmartin, M.R., Kwapis, J.L., Helmstetter, F.J.
Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex
Neurobiology of Learning & Memory 97, 300-306

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Jarome, T.J., Kwapis, J.L., Werner, C.T., Parsons, R.G., Gafford, G.M., Helmstetter, F.J.
The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation
Learning & Memory 19, 452-464

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Kwapis, J.L., Jarome, T.J., Gilmartin, M.R., Helmstetter, F.J.
Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts context fear memory
Neurobiology of Learning & Memory 98, 148-153

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2011

Kwapis, J.L., Jarome, T.J., Schiff, J.C., Helmstetter, F.J.
Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin
Learning & Memory 18, 728-732

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Jarome, T.J., Werner, C.T., Kwapis, J.L., Helmstetter, F.J.
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala
PLoS ONE 16(9), e24349

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Gafford, G.M., Parsons, R.G., Helmstetter, F.J.
Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus
Neuroscience 182, 98-104

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Balderston, N.L., Schultz, D.H., Helmstetter, F.J.
The human amygdala plays a stimulus specific role in the detection of novelty
Neuroimage 55(4), 1889-1898

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2010

Schultz, D.H., Helmstetter, F.J.
Classical conditioning of autonomic fear responses is independent of contingency awareness
Journal of Experimental Psychology: Animal Behavior Processes 36(4), 495-500

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Balderston, N.L., Helmstetter, F.J.
Conditioning with masked stimuli affects the timecourse of skin conductance responses
Behavioral Neuroscience 124(4), 478-489

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Gilmartin, M.R., Helmstetter, F.J.
Trace and contextual fear conditioning require neural activity and NMDA receptor-dependent transmission in the medial prefrontal cortex
Learning & Memory 17, 289-296

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Jarome, T.J., Kwapis, J.L., Nye, S., Helmstetter, F.J.
Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits
Behavior Genetics 40(1), 85-92

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Lonergan, M.E., Gafford, G.M., Jarome, T.J., Helmstetter, F.J.
Time-dependent expression of Arc and zif268 after acquisition of fear conditioning
Neural Plasticity

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Parsons, R., Gafford, G.M., Helmstetter, F.J.
Regulation of extinction-related plasticity by opioid receptors in the ventrolateral periaqueductal gray matter
Frontiers in Behavioral Neuroscience 4

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2009

Lee, T., Jarome, T.J., Li, S.J., Kim, J.J., Helmstetter, F.J.
Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study
Neuroreport 20(17), 1554-1558

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Kwapis, J.L., Jarome, T.J., Lonergan, M.E. & Helmstetter, F.J.
Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus
Behavioral Neuroscience 123, 844-850

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2008

Helmstetter, F.J., Parsons, R.G. Gafford, G.M.
Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning
Neurobiology of Learning and Memory 89, 324-337

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2007

Cheng, D.T., Richards, J., Helmstetter, F.J.
Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock
Learning & Memory 14(7), 485-490

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2006

Parsons, R.G., Gafford, G.M., Helmstetter, F.J.
Translational control via the mamilian target of rapamycin pathway is critical for the formation and stability of long term fear memory in amygdala neurons
Journal of Neuroscience 26(50), 12977-12983

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Cheng, D.T., Knight, D.C., Smith, C.N., Helmstetter, F.J.
Human amygdala activity during the expression of fear responses
Behavioral Neuroscience 120, 1187-1195

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Parsons, R.G., Riedner, B.A., Gafford, G.M., Helmstetter, F.J.
The formation of auditory fear memory requires the synthesis of protein and mRNA in the auditory thalamus
Neuroscience 141, 1163-1170

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Parsons, R.G., Gafford, G.M., Baruch, D.E., Riedner, B.A., Helmstetter, F.J.
Long term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala
European Journal of Neuroscience 23, 1853-1859

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2005

Shin, M.S., Helmstetter, F.J.
Antinociception following application of DAMGO to the basolateral amygdala results from a direct interaction of DAMGO with mu opioid receptors in the amygdala
Brain Research

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Gafford, G.M., Parsons, R.G. Helmstetter, F.J.
Effects of post training hippocampal injections of midazolam on fear conditioning
Learning & Memory 12, 573-578

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Earlier

Knight, D.C., Smith, C.N., Cheng, D.T., Stein, E.A., Helmstetter, F.J. (2004)
Amygdala and huppocampal activity during acquisition and extinction of human fear conditioning
Cognitive, Affective, and Behavioral Neuroscience 4(3), 317-325

Baruch, D.E., Swain, R.A., Helmstetter, F.J. (2004)
Effects of exercise on Pavlovian fear conditioning
Behavioral Neuroscience Oct 118(5), 1123-1127

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Knight, D.C., Cheng, D.T., Smith, C.N., Stein, E.A., Helmstetter, F.J. (2004)
Neural substrates mediating human delay and trace fear conditioning
Journal of Neuroscience 24(1), 218-228

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Cheng, D.T., Knight, D.C., Smith, C.N., Stein, E.A., Helmstetter, F.J. (2003)
Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression
Behavioral Neuroscience 117(1), 3-10

Bailey, D.J., Tetzlaff, J.E., Cook, J.M., He, X., Helmstetter, F.J. (2002)
Effects of hippocampal injections of a novel ligand selective for the alpha 5 beta 2 gamma 2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning
Neurobiology of Learning and Memory 78(1), 1-10

Kocorowski, L.H., Helmstetter, F.J. (2001)
Calcitonin gene-related peptide released within the amygdala is involved in Pavlovian auditory fear conditioning
Neurobiology of Learning and Memory 75(2), 149-163

Foo, H., Helmstetter, F.J. (2000)
Activation of kappa opioid receptors in the rostral ventromedial medulla blocks stress-induced antinociception
Neuroreport 11(15), 3349-3352

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Tershner, S.A., Helmstetter, F.J. (2000)
Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray
Brain Research 865(1), 17-26

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Foo, H., Helmstetter, F.J. (2000)
Expression of antinociception in response to a signal for shock is blocked after selective downregulation of mu-opioid receptors in the rostral ventromedial medulla
Brain Research: Molecular Brain Research 76(2), 282-288

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Knight, D.C., Smith. C.N., Stein, E.A., Helmstetter, F.J. (1999)
Functional MRI of human Pavlovian fear conditioning: patterns of activation as a function of learning
Neuroreport 10(17), 3665-3670

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Foo, H., Helmstetter, F.J. (1999)
Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but not a delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla
Pain 83(3), 427-431

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