Abstracts

1. "Expression and Mutagenesis of Para-Hydroxybenzoate Hydroxylase" Moran G. R. and Entsch B. Presented at the East Coast Protein Meeting, Byron Bay, New South Wales, Australia, Feb. 1993.

2. "Expression and Mutagenesis of Para-Hydroxybenzoate Hydroxylase" Moran G. R.,  Entsch B., and Ballou D. P., Presented at the XIV Midwest Enzyme Chemistry Conference, Chicago, IL, Oct. 1994.

3. "Unusual Properties Of Para-Hydroxybenzoate Hydroxylase Mutated In A Putative Proton Relay Residue." Palfey B.A., Dauber D.S., Moran G.R., Entsch B., Ballou D.P. Presented at the ASBMB Meeting, San Francisco, CA, Jul. 1995.

4. "Purification of A Stable Active Mutant of Tryptophan Hydroxylase" Moran G. R. and  Fitzpatrick P. F., Presented at the ASBMB Meeting, San Francisco, CA, Jul. 1997.

5. "Flavin movement during the reductive half-reaction of p-hydroxybenzoate hydroxylase" Palfey B.A., Moran G. R., Entsch B., Ballou D. P., Massey V.  Presented at the ASBMB Meeting, San Francisco, CA, Jul. 1997.

6. "Kinetic Studies of Truncated Rabbit Tryptophan Hydroxylase" Moran G. R. and Fitzpatrick P. F., Presented at the Steenbock Symposium, Madison, WI, Jul. 1998.

7. "Evidence for the Chemical Mechanism of Tryptophan Hydroxylase" Moran G. R. and Fitzpatrick P. F., Presented at the ICBIC symposium Minneapolis, MN, Aug. 1999.

8. "Identification of Reactive Intermediates in FeII Dependent Non-Heme Oxygenases" Moran G. R., Presented at the UW System Chemistry Faculty Conference, Riverfalls, WI, Oct. 1999.

9. "4-Hydroxyphenylpyruvate Dioxygenase and Homogentisate 1,2-Dioxygenase" Moran G. R. Presented at the Gordon Conference on Enzymes, Coenzymes and Metabolic Pathways, Kimball Union Academy, NH, Jul. 2000.

10. "Biophysical Chemistry at The University of Wisconsin Milwaukee" Moran G. R. Presented at the UW System Chemistry Faculty Conference, La Crosse, WI, Oct. 2000.

11. "Proton movements control the reduction of FAD in p-hydroxybenzoate hydroxylase." Palfey B. A., Frederick K. K., Moran G. R., Entsch B., Ballou D. P., Massey V. Presented at the ACS Meeting in Chicago, IL, Mar. 2000.

12. "Preliminary Studies of 4-hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis" Purpero V. M.,  Nelson T. N.,  and Moran G. R. Presented at the ACS Meeting in Chicago, IL, Aug. 2001.

13. "A Prelude to Kinetic and Structural Characterization of 4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis" Johnson-Winters K., Nelson T. N.,  and Moran G. R. Presented at the ACS Meeting in Chicago, IL, Aug. 2001.

14. "Studies of 4-hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis" Purpero V. M.,  and  Moran G. R. Presented at the 2002 Midwest Enzyme Chemistry Conference, Chicago, IL, Oct. 2001.

15. "Making 4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis Transparent." Johnson-Winters K., Nelson T. N., and Moran G. R. Presented at the 21st Midwest Enzyme Chemistry Conference, Chicago, IL, Oct. 2001.

16. "Preliminary Evidence of Intermediates in 4-Hydroxyphenylpyruvate Dioxygenase from Steptomyces avermitilis." Nelson T. N., Johnson-Winters K., Purpero, V. M., and Moran G. R. Presented at the Metals in Biology Gordon Conference, Ventura, CA, Jan. 2002.

17. "Crystallization and Kinetic Study of 4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis." Johnson-Winters K. and Moran G. R. Presented at the 21st Midwest Enzyme Chemistry Conference, Chicago, IL, Sep. 2002.

18. "A Mechanistic Investigation of 4–Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis Using Substrate Analogs." Purpero V. M. and Moran G. R. Presented at the 21st Midwest Enzyme Chemistry Conference, Chicago, IL, Sep. 2002.

19. "A Mechanistic Investigation of 4–Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis Using Substrate Analogs." Purpero V. M , Johnson-Winters, K., and Moran G. R. Presented at the Enzyme Mechanisms Conference, Glaveston, TX, Jan. 2003.

20. "Deuterium Isotope Effects and Crystallography as Mechanistic Probes of 4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis." Johnson-Winters K., Purpero V. M., and Moran G. R.  Presented at the Enzyme Mechanisms Conference, Glaveston, TX, Jan. 2003.

21. "Studies of the Interaction of Streptomyces avermitilis (4-hydroxyphenyl)pyruvate Dioxygenase with the Specific Inhibitor NTBC." Kavana  M., Neidig M., Solomon, E., and Moran G. R. Presented at the 29th Steenbock Symposium, Madison, WI, May 2003.

22. "A Mechanistic Investigation of 4–Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis Using Substrate Analogs". Purpero V. M., Johnson-Winters K., Kavana M., and Moran G. R. Presented at the 29th Steenbock Symposium, Madison WI, May 2003.

23. "Studies of the Interaction of Streptomyces avermitilis (4-hydroxyphenyl)pyruvate Dioxygenase with the Specific Inhibitor NTBC." Kavana M., and Moran G. R., presented at the 11th International Conference on Biological Inorganic Chemistry, Cairns, QLD (Australia) Jul. 2003.

24. "Alpha-keto acids and 4-hydroxyphenylpyruvate dioxygenase." Moran G. R, Purpero V. M., Johnson-Winters K., and Kavana M. Presented at the 11th International Conference on Biological Inorganic Chemistry, Cairns, QLD, (Australia) Jul. 2003.

25. "Studies of the Interaction of Streptomyces avermitilis (4-hydroxyphenyl)pyruvate Dioxygenase with the Specific Inhibitor NTBC." Kavana, M., and Moran G. R.  Presented at the 22nd Midwest Enzyme Conference, University of Chicago Illinois, Chicago, IL Oct. 2003.

26. "Intermediates In The Catalytic Cycle Of 4-Hydroxyphenylpyruvate Dioxygenase From Streptomyces avermitilis." Johnson-Winters K., Purpero V. M., and Moran G. R. Presented at the 22nd Midwest Enzyme Conference, University of Chicago Illinois, Chicago, IL, Oct. 2003.

27. "Preliminary Studies Of Homogentisate 1,2-Dioxygenase From Human And Pseudomonas aeruginosa." Steoger G., Amaya A. A., Brzezinski K. T., Farrington N., and Moran G. R. Presented at the 22nd Midwest Enzyme Conference, University of Chicago, Chicago, IL, Oct. 2003.

28. "Preliminary Studies of Homogentisate 1,2-Dioxygenase From Human."” Amaya A. A., Brzezinski K. T., Farrington N., and Moran G. R. Presented at the ACS conference, Anaheim CA, Mar. 2004.

29. "Catalytic and Inhibitory Phenomena of 4- Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitlis." Johnson-Winters K., Purpero V. M., Brownlee J., Harrison D. H. T., and Moran G. R. Presented at the Midwest Metals Meeting, Ann Arbor, MI, Jun. 2004.

30. "The Structure of NTBC Bound to 4-Hydroxyphenylpyruvate Dioxygenase." Brownlee J., Johnson-Winters K., Harrison D. H. T., and Moran G. R. Presented at American Crystallographic Association meeting IL, Jul. 2004.

31. "Structure-function correlations in the novel alpha-ketoglutarate-dependent dioxygenases HPPD and HmaS: Identical substrates but different reactivities." Neidig, M. L., Kavana M., Choroba, O. W.,  Moran G. R., Spencer J. B., and Solomon E. I., Presented at The American Chemical Society Meeting, Philedelphia PA, Aug. 2004.

32. "The Chemistry of Activation and Inhibition of 4-Hydroxyphenylpyruvate Dioxygenase." Moran G. R., Johnson-Winters K., Purpero V. M., Kavana M., Brownlee J., Harrison D.H.T., Neidig M. L., and Solomon E. I. Presented at the Enzymes, Coenzymes and metabolic Pathways Gordon Conference, Kimble Union Academy, NH, Jul. 2004.

33. "Kinetic Investigation Of 4-Hydroxyphenylpyruvate Dioxygenase From Streptomyces avermitilis" Johnson-Winters, K., Purpero, V. M., Brownlee, J.M., Harrison, D.H.T., Moran, G.R. Presented at the 24th Midwest Enzyme Conference, University of Chicago, Chicago, IL, Oct. 2004.

34. "A Mechanistic Insight: Fluorinated Substrate Analogues With (4–Hydroxyphenyl)Pyruvate Dioxygenase From Streptomyces avermitilis." Purpero, V.M. and Moran, G.R. Presented at the 24th Midwest Enzyme Conference, University of Chicago, Chicago, IL, Oct. 2004.

35. "(4-Hydroxyphenyl)Pyruvate Dioxygenase From Streptomyces avermitilis: Inhibition Studies" Kavana, M., and Moran G. R. Presented at the 24th Midwest Enzyme Conference, University of Chicago Illinois, Chicago, IL Oct. 2004.

36. "Accumulation Of Multiple Intermediates In The Catalytic Cycle Of 4-Hydroxyphenylpyruvate Dioxygenase From Streptomyces Avermitilis." Kayunta Johnson-Winters, Vincent M. Purpero, Michael Kavana and Graham R. Moran. Presented at the 25th Midwest Enzyme Conference, Loyola University, Chicago, IL Oct. 2005.

37. "A Pre-Steady State Investigation Of 4–Hydroxyphenylpyruvate Dioxygenase From Arabidopsis Thaliana: Viva Lo Intermediario! " Vincent M. Purpero and Graham R. Moran. Presented at the 25th Midwest Enzyme Conference, Loyola University, Chicago, IL Oct. 2005.

38. "Freeze-Quench Design to Trap Intermediates Catalyzed by (4-Hydroxphenyl)pyruvate Dioxygenase from Arabidopsis thaliana and mutants of Streptomyces avermitilis." Panqing He, Vincent M. Purpero, and Graham R. Moran. Presented at the 25th Midwest Enzyme Conference, Loyola University, Chicago, IL Oct. 2005.

39. "Kinetic Characterization Of Hydroxymandelate Synthase From Amycolatopsis Orientalis." John Conrad, and Graham Moran, Presented at the 25th Midwest Enzyme Conference, Loyola University, Chicago, IL Oct. 2005.

40. "Cloning, Purification, and Preliminary Observations of Kynurenine 3-Monoxygenase from Pseudomonas fluorescens." Karen Crozier and Graham R. Moran. Presented at the 25th Midwest Enzyme Conference, Loyola University, Chicago, IL Oct. 2005.

41." Spectroscopic and electronic structure studies of the non-heme iron enzymes HPPD and HmaS: Aromatic electrophilic attack vs. H-atom abstraction" Michael L. Neidig, Andrea Decker, Oliver W Choroba, Fanglu Huang, Michael Kavana, Graham R. Moran, Jonathan B Spencer, and Edward I. Solomon. Presented at the 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006.

42." Structural and Kinetic Characterization of 4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitlis." Kayunta Johnson-Winters and Graham R. Moran. Presented at the Rocky Mountains ACS Meeting, Tucson, Az, University of Arizona, October, 2006.

43." Substrate binding by (4-hydroxyphenyl)pyruvate dioxygenase: binding orientation and the importance of the C-terminus." Panqing He, Julie Dricken, F. Holger Försterling, and Graham R. Moran. Presented at the 26th Midwest Enzyme Conference, Northwestern University, Evanston, IL Oct. 2006.

44." Reductive Half Reaction Of Kynurenine 3-Monoxygenase From Pseudomonas Fluorescens." Karen Crozier And Graham Moran. Presented at the 26th Midwest Enzyme Conference, Northwestern University, Evanston, IL Oct. 2006.

45." Subcloning And Preliminary Expression Trials Of Kynurenine 3-Monoxygenase In Saccharomyces Cerevisiae." Judith Bates And Graham Moran. Presented at the 26th Midwest Enzyme Conference, Northwestern University, Evanston, IL Oct. 2006.

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